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What are the odds? Titans vs. Colts

The second meeting.

NFL: Indianapolis Colts at Tennessee Titans Christopher Hanewinckel-USA TODAY Sports

Through the years, the Tennessee Titans have had one constant thorn in their side. It’s been the Indianapolis Colts, seemingly no matter the year or who is playing quarterback for the franchise. We’ve already seen that story play out yet again this season.

Indianapolis came to Nashville just two weeks ago and took care of the Titans, capitalizing on a few special teams mistakes and dominating the second half to win 34-17. The win was a big one for Indy, giving them the lead in the AFC South race. After both teams held serve in tough games last week, another battle for the division lead will take place on Sunday.

Just like last time, Vegas gives us another close spread. This time they like the Colts, favoring Indianapolis by three points. The current total sits at 51.5. The line opened as large as 4.5 points, but has been worked down to three as of Friday morning.

For the Colts, they’re dealing with several injury situations. The most prominent is standout defensive tackle DeForest Buckner, who now will officially miss the game on the COVID list. Quenton Nelson, Philip Rivers, Rock Ya-Sin and Ryan Kelly are also question marks entering Friday, but we’ll know more later today.

The Titans have their own issues, still missing Adoree’ Jackson and with Jadeveon Clowney on injured reserve. They also lost linebacker Jayon Brown for the season last week. The offensive line continues to take hits, but that group continues to produce no matter what. Ty Sambrailo is the latest injury, which now means David Quessenberry’s number has been called.

A.J. Brown also missed some practice this week, but that’s become a common occurrence recently with his knee issue. Safety Kenny Vaccaro is on track to return following his concussion.

How each side adjusts to these absences will go a long way in determining a winner on Sunday. Luckily for the Titans, this is nothing new this season. However, as we all know, the Colts just find ways to come up big in these spots against this organization.

It’s an opportunity for both sides to take control of the AFC South, and it’s starting to get pretty late in the year.