The Bills opened as a 3 point favorite over the Titans at Nissan Stadium. The line has moved to as low as Titans +1 in some places. A lot of that probably has to do with the fact that it was announced today that Karlos Williams has a concussion. His status for Sunday's game is up in the air. The Bills will probably already be without LeSean McCoy, so they signed Boom Herron today.
The over/under for the game is currently 41.5. That is the lowest total currently on the board. The Bills have one of the best defenses in the league. Their front 7 is arguably the best in football. It will be tough for the Titans running back to find much room to run.
Marcus Mariota will need to be at his best in this one. Not that this isn't always the case, but it will be really important for him to take care of the football. This would also be a great game for him to use his legs to make some big plays.