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The Jaguars also weren't very good against the run last season. They gave up 121.6 yards per game and 4.7 yards per attempt. They did make some moves in the offseason to boost their run defense and will benefit from having Aaron Kampman back (although he is questionable for Sunday).
The Titans had some trouble running the ball against Jacksonville last season. Chris Johnson did have 111 yards in the first game, but 35 of those yards came on a late touchdown run after the game was in hand. He only had 53 yards in the second game.
This will be a good first test for the interior of the offensive line. All eyes are going to be on them, and on head coach Mike Munchak because he was the one that said from the beginning that this group was good enough to get it done.
Look for Jamie Harper to play a significant role in this game. As much as they are going to want to ride CJ, I still think it is going to be tough for him to handle much more than 14-16 carries. They are going to want to run the ball more than that, and Harper is going to get his chance to prove himself because it doesn't look like Javon Ringer will be ready to go.