| Name | Position | Injury | Practice Status | Game Status |
| TEN | ||||
| Jevon Kearse | DE | Not Injury Related | Did Not Participate In Practice | -- |
| Jason Jones | DT | Shoulder | Did Not Participate In Practice | Out |
| Colin Allred | LB | Hamstring | Did Not Participate In Practice | Doubtful |
| Sen'Derrick Marks | DT | Ankle | Did Not Participate In Practice | Questionable |
| Justin Gage | WR | Back | Full Participation in Practice | Questionable |
| Michael Griffin | S | Shoulder | Full Participation in Practice | Questionable |
| Jacob Ford | DE | Abdomen | Limited Participation in Practice | Questionable |
| Rob Bironas | K | right Ankle | Full Participation in Practice | Probable |
| IND | ||||
| Antoine Bethea | CB | Not Injury Related | Full Participation in Practice | -- |
| Donald Brown | RB | Chest | Did Not Participate In Practice | Out |
| Keyunta Dawson | DE | Knee | Did Not Participate In Practice | Out |
| Aaron Francisco | CB | Ankle | Did Not Participate In Practice | Out |
| Anthony Gonzalez | WR | Knee | Did Not Participate In Practice | Out |
| Adam Vinatieri | K | right Knee | Did Not Participate In Practice | Out |
| Charlie Johnson | T | Foot | Did Not Participate In Practice | Questionable |
| Jim Sorgi | QB | right Shoulder | Did Not Participate In Practice | Questionable |
| Dwight Freeney | DE | Abdomen | Full Participation in Practice | Questionable |
| Jerraud Powers | CB | Knee | Full Participation in Practice | Probable |
| Jamey Richard | G | Shoulder | Full Participation in Practice | Probable |
| Tom Santi | TE | Hand | Full Participation in Practice | Probable |
| Jeff Saturday | C | Calf | Full Participation in Practice | Probable |
| Reggie Wayne | WR | Foot | Full Participation in Practice | Probable |
| Tony Ugoh | T | Knee | Did Not Participate In Practice | Probable |
| Joseph Addai | RB | Knee | Full Participation in Practice | Probable |
| Gary Brackett | LB | Foot | Full Participation in Practice | Probable |
| Kyle DeVan | C | Shin | Full Participation in Practice | Probable |
| Kelvin Hayden | CB | Knee | Full Participation in Practice | Probable |
| Ramon Humber | LB | Calf | Full Participation in Practice | Probable |
| Tim Jennings | CB | Ankle | Full Participation in Practice | Probable |
| Peyton Manning | QB | Glute | Full Participation in Practice | Probable |
| Robert Mathis | DE | Neck | Full Participation in Practice | Probable |