| Name | Position | Injury | Practice Status | Game Status |
| SD | ||||
| Shawne Merriman | LB | Foot | Did Not Participate In Practice | Probable |
| Kevin Burnett | LB | Neck | Full Participation in Practice | Questionable |
| Nick Hardwick | C | Ankle | Full Participation in Practice | Questionable |
| Travis Johnson | DE | Groin | Full Participation in Practice | Probable |
| Legedu Naanee | WR | Foot | Full Participation in Practice | Probable |
| Mike Scifres | P | Left Groin | Full Participation in Practice | Probable |
| Jacques Cesaire | DE | Elbow | Limited Participation in Practice | Questionable |
| Scott Mruczkowski | G | Ankle | Out (Definitely Will Not Play) | Probable |
| TEN | ||||
| Tony Brown | DT | Knee | Full Participation In Practice | Probable |
| Nick Harper | CB | Shoulder | Full Participation In Practice | Questionable |
| Kyle Vanden Bosch | DE | Neck | Full Participation In Practice | Probable |
| Craig Stevens | TE | Concussion | Full Participation in Practice | Probable |
| Troy Kropog | T | Calf | Did Not Participate in Practice | Out |
| Nate Washington | WR | Ankle | Full Participation in Practice | Probable |
| Keith Bulluck | LB | Knee | Out (Definitely Will Not Play) | Out |