| Name | Position | Injury | Practice Status | Game Status |
| STL | ||||
| Kenneth Darby | RB | Illness | Did Not Participate In Practice | -- |
| Steven Jackson | RB | Back | Did Not Participate In Practice | -- |
| Jason Smith | T | Concussion | Did Not Participate In Practice | -- |
| Donnie Avery | WR | Shoulder | Limited Participation in Practice | -- |
| Kyle Boller | QB | Thigh | Limited Participation in Practice | -- |
| Brandon Gibson | WR | Ankle | Limited Participation in Practice | -- |
| Mike Karney | RB | Neck | Limited Participation in Practice | -- |
| James Laurinaitis | LB | Shoulder | Limited Participation in Practice | -- |
| Darell Scott | DT | Neck | Limited Participation in Practice | -- |
| Marc Bulger | QB | Knee | Out (Definitely Will Not Play) | -- |
| TEN | ||||
| Colin Allred | LB | Hamstring | Did Not Participate In Practice | -- |
| Jared Cook | TE | Concussion | Did Not Participate In Practice | -- |
| Ahmard Hall | RB | Ankle | Did Not Participate In Practice | -- |
| Jason Jones | DT | Shoulder | Did Not Participate In Practice | -- |
| David Thornton | LB | Not Injury Related | Did Not Participate In Practice | -- |
| Kenny Britt | WR | Back | Full Participation in Practice | -- |
| Nate Washington | WR | Ankle | Full Participation in Practice | -- |
| Tony Brown | DT | Not Injury Related | Limited Participation in Practice | -- |
| Chris Johnson | RB | Ankle | Limited Participation in Practice | -- |
| Kyle Vanden Bosch | DE | Not Injury Related | Limited Participation in Practice | -- |
| Vince Young | QB | Knee | Limited Participation in Practice | -- |
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