Not a lot of history between these two seeing that they are in different conferences. The 49ers lead the all-time series 7-4. The Titans won the last meeting 33-22 in the forgettable 2005 season. (As a side note; Steve McNair had 343 passing yards and 3 TDs in that game.)
The last time the Titans played in San Francisco was 1999 in a game won by the 9ers 24-22. (The Titans failed on a 2-point conversion late) Click on that link and look at the Titans offensive numbers from that day. Pretty funny stuff.
We will be treated to the broadcast duo of Ian Eagle and Rich Gannon for this late start on CBS.