Griffin has been substantially better than he was in 2012, and that is in large part thanks to the way that the Titans use him. The Titans have been using him primarily as a single-high safety whose primary responsibility has to keep the top on the defense, but he has also been very effective as a striking run-stopper. Griffin's new downhill style of play has sparked the defense on more than one occasion.
If the Titans are going to prevent a multiple offense from exploiting them like what happened in Denver, then they will need a good game from Michael Griffin. Another thing that the Titans need from Michael Griffin, is for him to finally tally his first interception of the year.
Carson Palmer has thrown 17 interceptions this season, and is known for throwing the ball directly at long-haired free safeties, (Troy Polamalu for example) and his inability to judge the defender's ability to break on the ball is legendary.
If Griffin can have a big day on defense, then it is hard to imagine the Cardinals putting up more than 17 points. The question is, can the Titans score 18 or more?