Knowing not nearly as much about defenses than the average Madden 2011 player, I wonder if the Titans could employ a 5-3 defense lining up 3 DTs, 2DEs, 3LBs, 2CB and one S. It would run similarly to the 85 Bears 46 defense with the main goal of disrupting the offense and getting to the QB. The key reason for adoption would be to get the Titan's best players on the field.
I have to imagine that this sort of defense would be suffocating against the run, and a high risk/reward against the pass, but vunerable against West Coast Offenses and spread formations.
Certainly, our defensive linemen (with AH) would be talented enough to pull it off, but I'm not sure if our LBs would be good enough to stop the type of slants and quick crossing patterns that would be typical against high-pressure defenses.
Not sure how it would work against spread formations, You would certainly have to get to the QB quickly as there would be a LB covering a WR.